Laboratory

Computational Systems Biology

Our laboratory applies systems biology approaches to understand the molecular mechanisms of infectious diseases and vaccine-induced immunity.

Principal Investigator: Helder Nakaya

Our 2015 Team 

Research

Systems Immunology

With the technological revolutions that occurred in the past decades, we are now able to access and integrate information about all the components within a biological system (e.g., genes, proteins, cells) and use it to compute and predict that system’s behavior. When applied to immunology, systems biology approaches can help us to understand the mechanisms by which pathogens and vaccines stimulate protective immunity.

Research

lncRNAs

It is estimated that thousands of long non-coding RNAs (lncRNAs) are transcribed in the genome of several organisms. Yet, only a small fraction of them have been functionally characterized. Studying the expression profile of lncRNAs and how their expression correlates with the expression of protein-coding genes in various tissues and conditions will reveal interesting mechanisms of gene regulation. 

Tools

CEMiTool

Systems Biology approaches provide a holistic view of biological processes, integrating the many different molecular components inside cells through highly complex networks. Our laboratory has developed a tool that identifies co-expression gene modules in an easy and reliable way.

Logo-2015-about

People

Our research is performed by a multidisciplinary team of students and collaborators.

Education

Courses, workshops and lectures related to bioinformatics and systems biology.

Blog

Latest news and papers related to Computational Systems Biology.

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Coffee Cups

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Lab members

FBC0415-6 Fisiopatologia I
Objetivos Fornecer aos alunos conhecimentos necessários à compreensão da epidemiologia e fisiopatologia das doenças infecciosas, hematológicas, imunológicas, do trato digestório
BeyondZika
Beyond Zika
Event Website Organizing committee: Raul Machado, PhD (University of São Paulo) Paola Minoprio. Ph.D. (Institut Pasteur, Paris) Luís Carlos Ferreira.
CRISPR-baby
Why CRISPR Gene Editing Will Change The World
Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction
R-Programming
Little Book of R for Bioinformatics
Suggested by Flavio   Welcome to a Little Book of R for Bioinformatics! By Avril Coghlan, Wellcome Trust Sanger Institute,

 

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