Laboratory

Computational Systems Biology

Our laboratory applies systems biology approaches to understand the molecular mechanisms of infectious diseases and vaccine-induced immunity.

Principal Investigator: Helder Nakaya

Our 2017-2018 Team 

Team 2017

Helder

Fernando

Thiago

Diogenes

Mindy

Pedro

Gustavo

Jaqueline

Fred

Fabio

Melissa

Natalia

Mariana

Patricia

Isabelle

David

Diogo

Lucas

Bruno

Cesar

Research

Systems Immunology

With the technological revolutions that occurred in the past decades, we are now able to access and integrate information about all the components within a biological system (e.g., genes, proteins, cells) and use it to compute and predict that system’s behavior. When applied to immunology, systems biology approaches can help us to understand the mechanisms by which pathogens and vaccines stimulate protective immunity.

Research

lncRNAs

It is estimated that thousands of long non-coding RNAs (lncRNAs) are transcribed in the genome of several organisms. Yet, only a small fraction of them have been functionally characterized. Studying the expression profile of lncRNAs and how their expression correlates with the expression of protein-coding genes in various tissues and conditions will reveal interesting mechanisms of gene regulation. 

Tools

CEMiTool

Systems Biology approaches provide a holistic view of biological processes, integrating the many different molecular components inside cells through highly complex networks. Our laboratory has developed a tool that identifies co-expression gene modules in an easy and reliable way.

Logo-2015-about

People

Our research is performed by a multidisciplinary team of students and collaborators.

Education

Courses, workshops and lectures related to bioinformatics and systems biology.

Blog

Latest news and papers related to Computational Systems Biology.

34,840,210

Coffee Cups

15

Lab members

A Guide to Reproducible Code (in Ecology and Evolution)
Suggested by Pedro “The fundamental idea behind a robust, reproducible analysis is a clean, repeatable script-based workflow (i.e. the sequence
Annual BBQ (2017)
   
Seeing Theory
Awesome website that shows a visual introduction to probability and statistics  
Bota Fora Thiago

 

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