Computational Systems Biology

Our laboratory applies systems biology approaches to understand the molecular mechanisms of infectious diseases and vaccine-induced immunity.

Principal Investigator: Helder Nakaya

Our 2015 Team 


Systems Immunology

With the technological revolutions that occurred in the past decades, we are now able to access and integrate information about all the components within a biological system (e.g., genes, proteins, cells) and use it to compute and predict that system’s behavior. When applied to immunology, systems biology approaches can help us to understand the mechanisms by which pathogens and vaccines stimulate protective immunity.



It is estimated that thousands of long non-coding RNAs (lncRNAs) are transcribed in the genome of several organisms. Yet, only a small fraction of them have been functionally characterized. Studying the expression profile of lncRNAs and how their expression correlates with the expression of protein-coding genes in various tissues and conditions will reveal interesting mechanisms of gene regulation. 



Systems Biology approaches provide a holistic view of biological processes, integrating the many different molecular components inside cells through highly complex networks. Our laboratory has developed a tool that identifies co-expression gene modules in an easy and reliable way.



Our research is performed by a multidisciplinary team of students and collaborators.


Courses, workshops and lectures related to bioinformatics and systems biology.


Latest news and papers related to Computational Systems Biology.


Coffee Cups


Lab members

CSBL members are the winners of Hackathon Hack4Health
Congratulations to Matheus and Pedro for winning the 2016 Brazil Hackathon Hack4Health!! HACK4HEALTH Hackathon Hack4Health. Oriundo dos tradicionais encontros e competições
FBC0415-6 Fisiopatologia I
Objetivos Fornecer aos alunos conhecimentos necessários à compreensão da epidemiologia e fisiopatologia das doenças infecciosas, hematológicas, imunológicas, do trato digestório
Beyond Zika
Event Website Organizing committee: Raul Machado, PhD (University of São Paulo) Paola Minoprio. Ph.D. (Institut Pasteur, Paris) Luís Carlos Ferreira.
Why CRISPR Gene Editing Will Change The World
Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction