Copyright: Immunity. 2010 Oct 29;33(4):516-29.
Systems vaccinology has recently emerged as an interdisciplinary field that combines systems-wide measurements, networks and predictive modeling in the context of vaccinology. For centuries, vaccines were developed empirically and with very little understanding of the mechanisms by which they mediate protective immunity. With the technological revolutions that occurred in the past decades, we are now able to access and integrate information about all the components within a biological system (e.g., genes, proteins, cells) and use it to compute and predict that system’s behavior. When applied to vaccinology, systems biology approaches can help us to understand the mechanisms by which vaccines stimulate protective immunity, and also to identify predictors of vaccine-induced immunity. Our recent papers highlight how systems vaccinology has led to the discovery of certain signatures that can predict the immunogenicity of influenza and yellow fever vaccines, and how its application towards basic immunology research may provide novel mechanistic insights about immune regulation.
Systems Vaccinology projects will be developed in collaboration with Dr. Bali Pulendran and his team, at Emory University.
Watch this video (in portuguese):
Nakaya HI, Pulendran B. (2015) Vaccinology in the era of high-throughput biology. Philos Trans R Soc Lond B Biol Sci. Jun 19;370(1671).
Hagan T, Nakaya HI, Subramaniam S, Pulendran B. (2015) Systems vaccinology: Enabling rational vaccine design with systems biological approaches. Vaccine. 2015 Sep 29;33(40):5294-301.
Nakaya HI (2013) Applying Systems Biology to Understand the Immune Response to Infection and Vaccination. Chapter of book “Computational Systems Biology, 2nd Ed”, Editors: Elis & Kriete, Publisher: Elsevier
Li S, Rouphael N, Duraisingham S, Romero-Steiner S, Presnell S, Davis C, Schmidt DS, Johnson SE, Milton A, Rajam G, Kasturi S, Carlone GM, Quinn C, Chaussabel D, Palucka AK, Mulligan MJ, Ahmed R, Stephens DS, Nakaya HI, Pulendran B. (2014) Molecular signatures of antibody responses derived from a systems biology study of five human vaccines. Nature immunology 15(2):195-204
Tan Y, Tamayo P, Nakaya HI, Pulendran B, Mesirov JP, Haining WN. (2014) Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response. European Journal of Immunology. 44, 1, 285–295
Ravindran R, Khan N, Nakaya HI, Li S, Loebbermann J, Maddur MS, Park Y, Jones DP, Chappert P, Davoust J, Weiss DS, Virgin HW, Ron D, Pulendran B. (2014) Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation. Science Jan 17;343(6168):313-7
Li S, Nakaya HI, Kazmin DA, Oh JZ, Pulendran B. (2013) Systems biological approaches to measure and understand vaccine immunity in humans. Semin Immunol. S1044-5323(13)00032-8
Pulendran B, Oh JZ, Nakaya HI, Ravindran R, Kazmin DA. (2013) Immunity to viruses: learning from successful human vaccines. Immunological Reviews, 255, (1) 243–255
Duraisingham S, Rouphael N, Cavanagh MM, Nakaya HI, Goronzy JJ and Pulendran B (2012) Systems Biology of Vaccination in the Elderly. Chapter of book “Current Topics in Microbiology and Immunology”, Editors: Michael G. Katze, Publisher: Springer
Nakaya HI and Pulendran B. (2012) Systems vaccinology: its promise and challenge for HIV vaccine development. Current Opinion in HIV & AIDS, Jan; 7(1):24-31
Nakaya HI, Gardner J, Poo YS, Major L, Pulendran B, Suhrbier A. (2012) Gene Profiling of Chikungunya Virus Arthritis Reveals Significant Overlap with Rheumatoid Arthritis. Arthritis & Rheumatism, Nov; 64(11):3553-63
Nakaya HI, Wrammert J, Lee EK, Racioppi L, Marie-Kunze S, Haining WN, Means AR, Kasturi SP, Khan N, Li GM, McCausland M, Kanchan V, Kokko KE, Li S, Elbein R, Mehta AK, Aderem A, Subbarao K, Ahmed R & Pulendran B. (2011) Systems biology analysis of vaccination for seasonal influenza in humans. Nature Immunology, Jul 10;12(8):786-95
Nakaya HI, Li S, Pulendran B. (2011) Systems Vaccinology: Learning to compute the behavior of vaccine induced immunity. Wiley Interdiscip Rev Syst Biol Med, Oct 19: DOI 10.1002/wsbm. 163
Pulendran B, Li S and Nakaya HI (2010) Systems Vaccinology. Immunity, Oct 29;33(4):516-29
Querec TD, Akondy RS, Lee EK, Cao W, Nakaya HI, Teuwen D, Pirani A, Gernert K, Deng J, Marzolf B, Kennedy K, Wu H, Bennouna S, Oluoch H, Miller J, Vencio RZ, Mulligan M, Aderem A, Ahmed R, Pulendran B (2009) Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nature Immunology, Jan;10(1):116-25